That depends on what therapy is best for you. Injections are the easiest to manage and titrate. The creams and gels are a little more difficult to determine absorption rates. Regardless of the therapy that best fits you it will depend on a number of factors. How severe is your condition? Do you have other medical factors that could contribute to challenges in therapy? What is your body fat percentage? Testosterone is a lipophylic, meaning it is absorbed through fat tissue in the body. Increased body fat could slow absorption. Most patients see improvement by week 4 of therapy with some getting near immediate results. If no improvement is experienced by week 12 the diagnosis should be reconsidered and alternatives should be explored.